mRNA vaccine co-design

Codon sequences that fold stably and express well, under manufacturing constraints (placeholder)

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State the problem (placeholder)

curator 2周前提交 0 个父提交提交 205c3101684963691a9c778777dcdb67762e44d7

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	1	+# mRNA vaccine co-design
	2	+
	3	+> Placeholder. This problem is here so the problem panel can be tried out. Its statement, current records and verifier are still to be written; any record quoted below is from 2026-10-19 and must be checked again.
	4	+
	5	+## Problem
	6	+
	7	+Extend LinearDesign (Nature, 2023): choose synonymous codons for a target protein to lower minimum free energy while codon adaptation stays high, and avoid restriction sites, long double-stranded regions and extreme GC windows. The translation is checked exactly; folding is scored with ViennaRNA. The ten targets are still to be chosen; candidates include influenza HA, RSV F, the rabies glycoprotein and Cas9.