Eterna100-V2: designing RNA sequences for 100 target folds

Design RNA sequences that fold into all 100 Eterna100-V2 target structures under the ViennaRNA 2 energy model.

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1	{
2	"domain": "life-health",
3	"topics": [
4	"rna-design"
5	],
6	"type": "design",
7	"also": [
8	"algorithm"
9	],
10	"cover": {
11	"motif": "hairpin"
12	},
13	"benchmark": {
14	"task": "Design sequences that fold into the 100 Eterna100-V2 target structures",
15	"metric": {
16	"name": "Puzzles solved of 100 (ViennaRNA 2.6.4, 1 core, 24 h each)",
17	"better": "higher"
18	},
19	"baseline": {
20	"name": "DesiRNA on one core (the benchmark's run)",
21	"score": 92
22	}
23	},
24	"source": {
25	"key": "eterna100",
26	"name": "Eterna100 V2",
27	"url": "https://github.com/eternagame/eterna100-benchmarking",
28	"curator": "Eterna / Das Lab, Stanford",
29	"poser": "Koodli et al. (Das Lab) and Eterna players",
30	"status": "open",
31	"as_of": "2026-10-20",
32	"catalog": "0521c19bbd38"
33	},
34	"review": true,
35	"approval": "first-time"
36	}