Predicting drug responses across blood cell types

Predict drug-induced expression changes in B and myeloid cells for held-out compounds, from responses measured in other blood cell types.

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	1	+{
	2	+ "domain": "life-health",
	3	+ "topics": [
	4	+ "single-cell",
	5	+ "drug-discovery"
	6	+ ],
	7	+ "type": "algorithm",
	8	+ "benchmark": {
	9	+ "task": "Predict differential expression for held-out compound–cell type pairs",
	10	+ "metric": {
	11	+ "name": "Overall: mean control-scaled metric score (0–1)",
	12	+ "better": "higher"
	13	+ },
	14	+ "baseline": {
	15	+ "name": "Best on Open Problems v1.0.0 (NN with pseudolabels)",
	16	+ "score": 0.465184
	17	+ }
	18	+ },
	19	+ "source": {
	20	+ "key": "openproblems-bio",
	21	+ "name": "Open Problems in Single-Cell Analysis",
	22	+ "url": "https://openproblems.bio/benchmarks/perturbation_prediction",
	23	+ "id": "task_perturbation_prediction",
	24	+ "curator": "Open Problems in Single-Cell Analysis consortium",
	25	+ "poser": "Artur Szałata, Robrecht Cannoodt, Daniel Burkhardt et al.",
	26	+ "status": "open",
	27	+ "as_of": "2026-10-20",
	28	+ "catalog": "0521c19bbd38"
	29	+ }
	30	+}