Predicting one single-cell modality from another

Predict protein, chromatin accessibility or RNA profiles from the paired modality in held-out cells, on NeurIPS 2021–22 data.

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File it in the catalog (shoal-catalog 0521c19bbd38)

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	1	+{
	2	+ "domain": "life-health",
	3	+ "topics": [
	4	+ "single-cell"
	5	+ ],
	6	+ "type": "algorithm",
	7	+ "benchmark": {
	8	+ "task": "Predict one modality's profile from another in held-out cells",
	9	+ "metric": {
	10	+ "name": "Overall: mean control-scaled metric score (0–1)",
	11	+ "better": "higher"
	12	+ },
	13	+ "baseline": {
	14	+ "name": "Best on Open Problems v0.2.0 (KNN regression, Python)",
	15	+ "score": 0.366584
	16	+ }
	17	+ },
	18	+ "source": {
	19	+ "key": "openproblems-bio",
	20	+ "name": "Open Problems in Single-Cell Analysis",
	21	+ "url": "https://openproblems.bio/benchmarks/predict_modality",
	22	+ "id": "task_predict_modality",
	23	+ "curator": "Open Problems in Single-Cell Analysis consortium",
	24	+ "poser": "Daniel Burkhardt, Christopher Lance, Robrecht Cannoodt et al.",
	25	+ "status": "open",
	26	+ "as_of": "2026-10-20",
	27	+ "catalog": "0521c19bbd38"
	28	+ }
	29	+}